Genetic model developed to detect breast cancer, women may benefit

Breast Cancer: Breast cancer is the most common type of cancer in women. According to the World Health Organization (WHO), 2.3 million new cases are reported every year. Because of this, many women lose their lives. However, in a research, it has been said to resort to genetic models to detect this disease.

Research on breast cancer

A team of researchers in the US has developed a new genetic model for breast cancer, which can help scientists understand why and where the cancer spreads.

Professor Eran Andrechek of Michigan State University in the US is researching the E2F5 gene and its role in the development of breast cancer.

What are the results?

Based on the results from Andrechak's laboratory, it can be said that the destruction of E2F5 changes the regulation of Cyclin D1. Cycline D1 is a protein associated with long-delayed metastatic breast tumors.

A study published in the journal 'Oncogene' has also reported that the removal of E2F5 in the memory gland leads to the formation of tumors. As scientists better understand how genes affect breast cancer, they will also be able to learn why cancer metastasizes and where the cancer is likely to spread.

What did the researcher say?

According to Andrecheck, his mouse model is different from the genetically prepared model. While genetically engineered mouse models can be artificially altered by injection to force cancer cells to travel to organs such as the liver or brain, his lab's newly created mouse model makes this unnecessary.

"One of the reasons we're so excited about this model is that it does something that most genetically engineered mouse models haven't done before," Andrecek said.

How was the study done?

Andrechek's lab uses bioinformatics along with genetic models to investigate the mechanisms involved in the development and progression of breast cancer.

Its research focuses on understanding breast tumor development and uses a range of methods, from animal models to computational analysis of gene expression data. Although breast cancer can occur at any age, most women are in their 60s or 70s when they are first diagnosed with the disease.

Andrechak's research is physiologically relevant because it takes about years for mice to develop tumours, which means that mice are getting breast cancer at the same age as women.

Disclaimer: Dear reader, thank you for reading our news, this news has been written only for the purpose of making you aware.